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When ROS levels exceed those of antioxidant defenses, there is an aberrant increase in free radical generation resulting in mitochondrial damage and leading to oxidative stress and subsequently this increased stress can reduce ETC activity (Gu et al., 2013) (Figure 2)

Physiology, pharmacology and clinical relevance of GLP-1 GLP-1 is a peptide hormone produced within the L cells of the intestine

These other mutants were showed here merely to avoid manipulating the image for not showing them

PA and B12 deficiency (unless it is caused purely by dietary lack) are caused due to an inability to absorb B12 from food and therefore B12 injections are required to bypass the stomach