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Cleveland Clinics health articles are based on evidence-backed information and review by medical professionals to ensure accuracy, reliability and up-to-date clinical standards

Patients should discuss any complementary therapies with their healthcare provider to ensure safety and avoid interactions with conventional treatment

Contraindications include personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, severe pancreatitis, diabetic retinopathy requiring caution, and pregnancy or breastfeeding

Perhaps the biggest splash to the GLP-RA pool has come with the PIONEER trials for oral semaglutide