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When someone applies for life insurance after losing weight on GLP-1 medications, underwriters see what looks like a healthy person with: Normal BMI Improved blood pressure Better cholesterol levels Lower HbA1c levels But here's the catch: Research from the landmark STEP 1 trial extension shows that participants regain approximately two-thirds of their prior weight loss within one year of stopping semaglutide (Wilding et al., 2022)

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Anti-inflammatory effects of exendin-4, a glucagon-like peptide-1 analog, on human peripheral lymphocytes in patients with type 2 diabetes